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Genetics in Keratoconus - What is New?


ABSTRACT: BACKGROUND:Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. CONCLUSION:The review focuses on current knowledge of these genetic risk factors associated with keratoconus.

SUBMITTER: Moussa S 

PROVIDER: S-EPMC5585456 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Genetics in Keratoconus - What is New?

Moussa Sarah S   Grabner Günther G   Ruckhofer Josef J   Dietrich Marie M   Reitsamer Herbert H  

The open ophthalmology journal 20170731


<h4>Background</h4>Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease.<h4>Conclusion</h4>The review focuses on current knowledge of these gene  ...[more]

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