Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
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ABSTRACT:
SUBMITTER: Singh AK
PROVIDER: S-EPMC5587609 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
Singh Appu K AK Saotome Kei K Sobolevsky Alexander I AI
Scientific reports 20170906 1
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states. ...[more]
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