Ontology highlight
ABSTRACT:
SUBMITTER: Singh AK
PROVIDER: S-EPMC6093632 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Singh Appu K AK McGoldrick Luke L LL Twomey Edward C EC Sobolevsky Alexander I AI
Science advances 20180815 8
Calcium (Ca<sup>2+</sup>) plays a major role in numerous physiological processes. Ca<sup>2+</sup> homeostasis is tightly controlled by ion channels, the aberrant regulation of which results in various diseases including cancers. Calmodulin (CaM)-mediated Ca<sup>2+</sup>-induced inactivation is an ion channel regulatory mechanism that protects cells against the toxic effects of Ca<sup>2+</sup> overload. We used cryo-electron microscopy to capture the epithelial calcium channel TRPV6 (transient re ...[more]