Ontology highlight
ABSTRACT:
SUBMITTER: Balaraman K
PROVIDER: S-EPMC5589145 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Synthesis 20160420 15
Sequential chlorination/fluorination of aromatic trifluoroacetylated ketones gives 1-aryl 2-chloro-2,4,4,4-tetrafluoro-butan-1,3-dione hydrates that are used for the synthesis of ketones and alkenes exhibiting a terminal bromochlorofluoromethyl group. The hydrates undergo detrifluoroacetylative cleavage and subsequent bromination in the presence of a copper(II)bisoxazoline catalyst, K<sub>2</sub>CO<sub>3</sub> and NBS at room temperature. The corresponding bromochlorofluoromethyl ketones can be ...[more]