Ontology highlight
ABSTRACT:
SUBMITTER: Gupta P
PROVIDER: S-EPMC5589182 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gupta Pranav P Xie Meina M Narayanan Silpa S Wang Yi-Jun YJ Wang Xiu-Qi XQ Yuan Timothy T Wang Ziyue Z Yang Dong-Hua DH Chen Zhe-Sheng ZS
Journal of cellular biochemistry 20170503 10
Overexpression of multidrug-resistant efflux transporters is one of the major causes of chemotherapy failure. MRP1, a 190 kDa efflux transporter, confers resistance to a wide of range of chemotherapeutic drugs. Here we study the cellular effects of GSK1904529A in reversing MRP1-mediated drug resistance. Cytotoxicity of GSK1904529A was determined by MTT assay. Reversal effects of GSK1904529A in combination with MRP1 substrates were determined. The intracellular accumulation and efflux of MRP1 sub ...[more]