Ontology highlight
ABSTRACT:
SUBMITTER: Ji N
PROVIDER: S-EPMC6591272 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ji Ning N Yang Yuqi Y Cai Chao-Yun CY Wang Jing-Quan JQ Lei Zi-Ning ZN Wu Zhuo-Xun ZX Cui Qingbin Q Yang Dong-Hua DH Chen Zhe-Sheng ZS Kong Dexin D
Frontiers in oncology 20190618
Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus, MDR is often results in treatment failure in the clinic. In this study, we found midostaurin, a Food and Drug Administration (FDA)-approved anti-leukemia drug, can antagonize ATP-binding cassette subfamily B member 1 (ABCB1)-mediated MDR. Our results indicated that midostaurin has the capacity to antagonize ABCB1-mediat ...[more]