Ontology highlight
ABSTRACT:
SUBMITTER: Deshpande CN
PROVIDER: S-EPMC5589216 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Deshpande Chandrika N CN Xin Vicky V Lu Yan Y Savage Tom T Anderson Gregory J GJ Jormakka Mika M
PloS one 20170907 9
Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism. Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the efficiency of this process by oxidizing the transported iron to its ferric form and promoting its release from ferroportin. Deletion or mutation of the hephaestin gene leads to systemic anemia with iron accumulation in the intestinal epithe ...[more]