Ontology highlight
ABSTRACT:
SUBMITTER: Punzo F
PROVIDER: S-EPMC5589594 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Punzo Francesca F Tortora Chiara C Di Pinto Daniela D Manzo Iolanda I Bellini Giulia G Casale Fiorina F Rossi Francesca F
Oncotarget 20170413 33
Osteosarcoma is the most common and aggressive bone tumor in children. The Endocannabinoid/Endovanilloid system has been proposed as anticancer target in tumor of different origins. This system is composed of two receptors (CB1 and CB2), the Transient Potential Vanilloid 1 (TRPV1) channel and their ligands and enzymes. CB1 is expressed mainly in central nervous system while CB2 predominantly on immune and peripheral cells. We investigated the effects of JWH-133 (CB2 agonist) and RTX (TRPV1 agoni ...[more]