Ontology highlight
ABSTRACT:
SUBMITTER: Coombs CC
PROVIDER: S-EPMC5591073 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Coombs Catherine C CC Zehir Ahmet A Devlin Sean M SM Kishtagari Ashwin A Syed Aijazuddin A Jonsson Philip P Hyman David M DM Solit David B DB Robson Mark E ME Baselga José J Arcila Maria E ME Ladanyi Marc M Tallman Martin S MS Levine Ross L RL Berger Michael F MF
Cell stem cell 20170810 3
Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes, commonly occurs among aging human hematopoietic stem cells. We analyzed deep-coverage, targeted, next-generation sequencing (NGS) data of paired tumor and blood samples from 8,810 individuals to assess the frequency and clinical relevance of CH in patients with non-hematologic malignancies. We identified CH in 25% of cancer patients, with 4.5% harboring presumptive leukemia driver mutations (CH-P ...[more]