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Uncovering the effect of low-frequency static magnetic field on tendon-derived cells: from mechanosensing to tenogenesis.

ABSTRACT: Magnetotherapy has been receiving increased attention as an attractive strategy for modulating cell physiology directly at the site of injury, thereby providing the medical community with a safe and non-invasive therapy. Yet, how magnetic field influences tendon cells both at the cellular and molecular levels remains unclear. Thus, the influence of a low-frequency static magnetic field (2?Hz, 350 mT) on human tendon-derived cells was studied using different exposure times (4 and 8?h; short-term studies) and different regimens of exposure to an 8h-period of magnetic stimulation (continuous, every 24?h or every 48?h; long-term studies). Herein, 8?h stimulation in short-term studies significantly upregulated the expression of tendon-associated genes SCX, COL1A1, TNC and DCN (p?2+ levels (p?

SUBMITTER: Pesqueira T

PROVIDER: S-EPMC5591251 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Uncovering the effect of low-frequency static magnetic field on tendon-derived cells: from mechanosensing to tenogenesis.

Pesqueira Tamagno T Costa-Almeida Raquel R Gomes Manuela E ME

Scientific reports 20170908 1

Magnetotherapy has been receiving increased attention as an attractive strategy for modulating cell physiology directly at the site of injury, thereby providing the medical community with a safe and non-invasive therapy. Yet, how magnetic field influences tendon cells both at the cellular and molecular levels remains unclear. Thus, the influence of a low-frequency static magnetic field (2 Hz, 350 mT) on human tendon-derived cells was studied using different exposure times (4 and 8 h; short-term ...[more]

PMID: 28887547

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