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HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in CETP, ABCA1, APOC3, and GALNT2.


ABSTRACT: To investigate whether HDL-C level in pregnant Chinese Han women of late second trimester correlated with loci in high-density lipoprotein-cholesterol (HDL-C)-related genes found in genome-wide association studies (GWAS).Seven single-nucleotide polymorphisms (rs3764261 in CETP, rs1532085 in LIPC, rs7241918 in LIPG, rs1883025 in ABCA1, rs4225 in APOC3, rs1059611 in LPL, and rs16851339 in GALNT2) were genotyped using the Sequenom MassArray system for 1,884 pregnant women.The following polymorphisms were statistically associated with HDL-C level after adjusting for age, gestational week, pre-pregnancy BMI and state of GDM or HOMAIR: (i) rs3764261 (b = -0.055 mmol/L, 95% CI -0.101 to -0.008, p = 0.021), (ii) rs1883025 (b = -0.054 mmol/L, 95% CI -0.097 to -0.012, p = 0.013), (iii) rs4225 (b = -0.071 mmol/L, 95% CI -0.116 to -0.027, p = 1.79E-3) and (iv) rs16851339 (b = -0.064 mmol/L, 95% CI -0.120 to -0.008, p = 0.025). The more risk alleles the pregnant women have, the lower the plasma HDL-C levels of the subjects are.Several risk alleles found to be related to HDL-C in GWAS are also associated with HDL-C levels in pregnant Chinese Han women and these risk loci contribute additively to low HDL-C levels.

SUBMITTER: Cui M 

PROVIDER: S-EPMC5593597 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in <i>CETP, ABCA1, APOC3,</i> and <i>GALNT2</i>.

Cui Mingxuan M   Li Wei W   Ma Liangkun L   Ping Fan F   Liu Juntao J   Wu Xueyan X   Mao Jiangfeng J   Wang Xi X   Nie Min M  

Oncotarget 20170524 34


<h4>Objective</h4>To investigate whether HDL-C level in pregnant Chinese Han women of late second trimester correlated with loci in high-density lipoprotein-cholesterol (HDL-C)-related genes found in genome-wide association studies (GWAS).<h4>Methods</h4>Seven single-nucleotide polymorphisms (rs3764261 in <i>CETP</i>, rs1532085 in <i>LIPC</i>, rs7241918 in <i>LIPG</i>, rs1883025 in <i>ABCA1</i>, rs4225 in <i>APOC3</i>, rs1059611 in <i>LPL</i>, and rs16851339 in <i>GALNT2</i>) were genotyped usin  ...[more]

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