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Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.


ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. DLBCL exhibits highly aggressive and systemic progression into multiple tissues in patients, particularly in lymph nodes. Whole-body 18F-fluodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging has an essential role in diagnosing DLBCL in the clinic; however, [18F]FDG-PET often faces difficulty in differentiating malignant tissues from certain nonmalignant tissues with high glucose uptake. We have developed a PET imaging strategy for DLBCL that targets poly[ADP ribose] polymerase 1 (PARP1), the expression of which has been found to be much higher in DLBCL than in healthy tissues. In a syngeneic DLBCL mouse model, this PARP1-targeted PET imaging approach allowed us to discriminate between malignant and inflamed lymph nodes, whereas [18F]FDG-PET failed to do so. Our PARP1-targeted PET imaging approach may be an attractive addition to the current PET imaging strategy to differentiate inflammation from malignancy in DLBCL.

SUBMITTER: Tang J 

PROVIDER: S-EPMC5594659 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.

Tang Jun J   Salloum Darin D   Carney Brandon B   Brand Christian C   Kossatz Susanne S   Sadique Ahmad A   Lewis Jason S JS   Weber Wolfgang A WA   Wendel Hans-Guido HG   Reiner Thomas T  

Proceedings of the National Academy of Sciences of the United States of America 20170821 36


Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. DLBCL exhibits highly aggressive and systemic progression into multiple tissues in patients, particularly in lymph nodes. Whole-body <sup>18</sup>F-fluodeoxyglucose positron emission tomography ([<sup>18</sup>F]FDG-PET) imaging has an essential role in diagnosing DLBCL in the clinic; however, [<sup>18</sup>F]FDG-PET often faces difficulty in differentiating malignant tissues from certain nonmalignant tissues with high g  ...[more]

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