Ontology highlight
ABSTRACT:
SUBMITTER: Ye G
PROVIDER: S-EPMC5595136 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Theranostics 20170802 13
MicroRNAs (miRNAs) play important roles in regulating tumour development and progression. Here we show that miR-647 is repressed in gastric cancer (GC), and associated with GC metastasis. Moreover, we identify that miR-647 can suppress GC cell migration and invasion <i>in vitro</i>. Mechanistically, we confirm miR-647 directly binds to the 3' untranslated regions of SRF mRNA, and SRF binds to the CArG box located at the MYH9 promoter. CCG-1423, an inhibitor of RhoA/SRF-mediated gene transcriptio ...[more]