Ontology highlight
ABSTRACT:
SUBMITTER: Ozturk E
PROVIDER: S-EPMC5597002 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Öztürk Ece E Arlov Øystein Ø Aksel Seda S Li Ling L Ornitz David M DM Skjåk-Bræk Gudmund G Zenobi-Wong Marcy M
Advanced functional materials 20160323 21
Deciphering the roles of chemical and physical features of the extracellular matrix (ECM) is vital for developing biomimetic materials with desired cellular responses in regenerative medicine. Here, we demonstrate that sulfation of biopolymers, mimicking the proteoglycans in native tissues, induces mitogenicity, chondrogenic phenotype, and suppresses catabolic activity of chondrocytes, a cell type that resides in a highly sulfated tissue. We show through tunable modification of alginate that inc ...[more]