Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5599183 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Li Yang Y Brauer Patrick M PM Singh Jastaranpreet J Xhiku Sintia S Yoganathan Kogulan K Zúñiga-Pflücker Juan Carlos JC Anderson Michele K MK
Stem cell reports 20170810 3
Hematopoietic stem cells arise from mesoderm-derived hemogenic endothelium (HE) during embryogenesis in a process termed endothelial-hematopoietic transition (EHT). To better understand the gene networks that control this process, we investigated the role of the transcription factor HEB (TCF12) by disrupting the TCF12 gene locus in human embryonic stem cells (hESCs) and inducing them to differentiate toward hematopoietic outcomes. HEB-deficient hESCs retained key features of pluripotency, includ ...[more]