Ontology highlight
ABSTRACT:
SUBMITTER: Bosse KR
PROVIDER: S-EPMC5600520 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Bosse Kristopher R KR Raman Pichai P Zhu Zhongyu Z Lane Maria M Martinez Daniel D Heitzeneder Sabine S Rathi Komal S KS Kendsersky Nathan M NM Randall Michael M Donovan Laura L Morrissy Sorana S Sussman Robyn T RT Zhelev Doncho V DV Feng Yang Y Wang Yanping Y Hwang Jennifer J Lopez Gonzalo G Harenza Jo Lynne JL Wei Jun S JS Pawel Bruce B Bhatti Tricia T Santi Mariarita M Ganguly Arupa A Khan Javed J Marra Marco A MA Taylor Michael D MD Dimitrov Dimiter S DS Mackall Crystal L CL Maris John M JM
Cancer cell 20170901 3
We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target safety and efficacy. Here, we show that GPC2 is a strong candidate immunotherapeutic target in this childhood cancer. We demonstrate high GPC2 expression in neuroblastoma due to MYCN transcriptional activation and/or somatic gain of the GPC2 locus. We confirm GPC2 to be highly expressed on most neuroblastomas, but not d ...[more]