Ontology highlight
ABSTRACT:
SUBMITTER: Guan S
PROVIDER: S-EPMC5788662 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Guan Shan S Lu Jiaxiong J Zhao Yanling Y Yu Yang Y Li Hui H Chen Zhenghu Z Shi Zhongcheng Z Liang Haoqian H Wang Mopei M Guo Kevin K Chen Xiangmei X Sun Wenjing W Bieerkehazhi Shayahati S Xu Xin X Sun Surong S Agarwal Saurabh S Yang Jianhua J
Oncotarget 20171220 2
Maternal embryonic leucine zipper kinase (MELK) is known to modulate intracellular signaling and control cellular processes. However, the role of MELK in oncogenesis is not well defined. In this study, using two microarray datasets of neuroblastoma (NB) patients, we identified that MELK expression is significantly correlated to poor overall survival, unfavorable prognosis, and high-risk status. We found that MELK is a direct transcription target of MYCN and MYC in NB, and MYCN increases MELK exp ...[more]