Ontology highlight
ABSTRACT:
SUBMITTER: Rotty JD
PROVIDER: S-EPMC5601320 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rotty Jeremy D JD Brighton Hailey E HE Craig Stephanie L SL Asokan Sreeja B SB Cheng Ning N Ting Jenny P JP Bear James E JE
Developmental cell 20170831 5
The Arp2/3 complex nucleates branched actin, forming networks involved in lamellipodial protrusion, phagocytosis, and cell adhesion. We derived primary bone marrow macrophages lacking Arp2/3 complex (Arpc2<sup>-/-</sup>) and directly tested its role in macrophage functions. Despite protrusion and actin assembly defects, Arpc2<sup>-/-</sup> macrophages competently phagocytose via FcR and chemotax toward CSF and CX3CL1. However, CR3 phagocytosis and fibronectin haptotaxis, both integrin-dependent ...[more]