Ontology highlight
ABSTRACT:
SUBMITTER: Chojnacki J
PROVIDER: S-EPMC5601426 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Chojnacki Jakub J Waithe Dominic D Carravilla Pablo P Huarte Nerea N Galiani Silvia S Enderlein Jörg J Eggeling Christian C
Nature communications 20170915 1
Human immunodeficiency virus type 1 (HIV-1) assembles as immature particles, which require the proteolytic cleavage of structural polyprotein Gag and the clustering of envelope glycoprotein Env for infectivity. The details of mechanisms underlying Env clustering remain unknown. Here, we determine molecular dynamics of Env on the surface of individual HIV-1 particles using scanning fluorescence correlation spectroscopy on a super-resolution STED microscope. We find that Env undergoes a maturati ...[more]