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Persistent impairments 3 years after (neo)adjuvant chemotherapy for breast cancer: results from the MaTox project.


ABSTRACT: PURPOSE:Although treatment for early breast cancer improved prognosis greatly, it can have significant long-term consequences, which must be considered during treatment decision. METHODS:453 patients with neoadjuvant or adjuvant treatment intention were recruited into the MaTox project within the prospective, multicentre, population-based German TMK cohort study (Tumour Registry Breast Cancer) between 2008 and 2009. Patient-reported outcomes (PROs) on 26 treatment-related symptoms were assessed via a specifically designed questionnaire at 4 weeks, 6 months, 18 months and 3 years after start of systemic treatment. RESULTS:The results show that alterations in smell, taste and appetite were clearly improved 3 years after treatment. In contrast, post-surgical symptoms, restrictions in memory/attention, musculoskeletal system and polyneuropathy worsened substantially over time and were persistent after 3 years: 78% of the patients recorded impairment in memory, 73% muscle pain, 67% pain at the operated site and 57% paraesthesia in fingers or toes. A logistic regression model showed that risk factors for developing persistent paraesthesia symptoms were age, early paraesthesia symptoms and taxane-based therapy. CONCLUSIONS:Our data show that most patients with breast cancer have persistent impairments negatively influencing their daily life even 3 years after treatment. Furthermore, we highlight areas requiring special attention in follow-up care.

SUBMITTER: Hurtz HJ 

PROVIDER: S-EPMC5602000 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Persistent impairments 3 years after (neo)adjuvant chemotherapy for breast cancer: results from the MaTox project.

Hurtz Hans-Jürgen HJ   Tesch Hans H   Göhler Thomas T   Hutzschenreuter Ulrich U   Harde Johanna J   Kruggel Lisa L   Jänicke Martina M   Marschner Norbert N  

Breast cancer research and treatment 20170705 3


<h4>Purpose</h4>Although treatment for early breast cancer improved prognosis greatly, it can have significant long-term consequences, which must be considered during treatment decision.<h4>Methods</h4>453 patients with neoadjuvant or adjuvant treatment intention were recruited into the MaTox project within the prospective, multicentre, population-based German TMK cohort study (Tumour Registry Breast Cancer) between 2008 and 2009. Patient-reported outcomes (PROs) on 26 treatment-related symptoms  ...[more]

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