Ontology highlight
ABSTRACT:
SUBMITTER: Omrani A
PROVIDER: S-EPMC5603719 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Omrani A A van der Vaart T T Mientjes E E van Woerden G M GM Hojjati M R MR Li K W KW Gutmann D H DH Levelt C N CN Smit A B AB Silva A J AJ Kushner S A SA Elgersma Y Y
Molecular psychiatry 20150428 11
Cognitive impairments are a major clinical feature of the common neurogenetic disease neurofibromatosis type 1 (NF1). Previous studies have demonstrated that increased neuronal inhibition underlies the learning deficits in NF1, however, the molecular mechanism underlying this cell-type specificity has remained unknown. Here, we identify an interneuron-specific attenuation of hyperpolarization-activated cyclic nucleotide-gated (HCN) current as the cause for increased inhibition in Nf1 mutants. Me ...[more]