Dataset Information

Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study.

ABSTRACT:

Aim

The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus.

Methods

This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) and estimated GFR (eGFR, <60?mL/min/1.73?m² versus ?60?mL/min/1.73?m²).

Results

A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r = 0.297, P < 0.001) and eGFR (r = -0.220, P < 0.001). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r = 0.150, P < 0.001). Also, baPWV was correlated positively with the ACR in patients with an eGFR???60?mL/min/1.73?m² (r = 0.146, P < 0.001). However, baPWV was not correlated with eGFR after adjustment for significant clinical variables.

Conclusions

The present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in GFR in patients with type 2 diabetes mellitus.

SUBMITTER: Kim JH

PROVIDER: S-EPMC5603750 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study.

Kim Jong Ho JH Kim Sang Soo SS Kim In Joo IJ Kim Bo Hyun BH Park Ja Young JY Lee Chang Won CW Suk Ji Hye JH Shin Sun Hae SH Son Sung Pyo SP Kim Min Chul MC Ahn Jun Hyeob JH Lee Kwang Jae KJ Kwon Min Jung MJ Lee Soon Hee SH Park Jeong Hyun JH

Journal of diabetes research 20170816

<h4>Aim</h4>The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus.<h4>Methods</h4>This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalb ...[more]

PMID: 28951879

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Dataset Information

Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study.

Aim

Methods

Results

Conclusions

Publications

Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study.

Similar Datasets

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