Ontology highlight
ABSTRACT:
SUBMITTER: Milner PJ
PROVIDER: S-EPMC4820280 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Organometallics 20150820 19
A thorough investigation of the challenging Pd-catalyzed fluorination of five-membered heteroaryl bromides is presented. Crystallographic studies and density functional theory (DFT) calculations suggest that the challenging step of this transformation is C-F reductive elimination of five-membered heteroaryl fluorides from Pd(II) complexes. On the basis of these studies, we have found that various heteroaryl bromides bearing phenyl groups in the ortho position can be effectively fluorinated under ...[more]