Ontology highlight
ABSTRACT:
SUBMITTER: Lister N
PROVIDER: S-EPMC5603994 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Lister Nicholas N Shevchenko Galina G Walshe James L JL Groen Jessica J Johnsson Per P Vidarsdóttir Linda L Grander Dan D Ataide Sandro F SF Morris Kevin V KV
Proceedings of the National Academy of Sciences of the United States of America 20170828 37
RNA has been found to interact with chromatin and modulate gene transcription. In human cells, little is known about how long noncoding RNAs (lncRNAs) interact with target loci in the context of chromatin. We find here, using the phosphatase and tensin homolog (PTEN) pseudogene as a model system, that antisense lncRNAs interact first with a 5' UTR-containing promoter-spanning transcript, which is then followed by the recruitment of DNA methyltransferase 3a (DNMT3a), ultimately resulting in the t ...[more]