Exploring regulation in tissues with eQTL networks.
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ABSTRACT:
SUBMITTER: Fagny M
PROVIDER: S-EPMC5604022 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Exploring regulation in tissues with eQTL networks.
Fagny Maud M Paulson Joseph N JN Kuijjer Marieke L ML Sonawane Abhijeet R AR Chen Cho-Yi CY Lopes-Ramos Camila M CM Glass Kimberly K Quackenbush John J Platig John J
Proceedings of the National Academy of Sciences of the United States of America 20170829 37
Characterizing the collective regulatory impact of genetic variants on complex phenotypes is a major challenge in developing a genotype to phenotype map. Using expression quantitative trait locus (eQTL) analyses, we constructed bipartite networks in which edges represent significant associations between genetic variants and gene expression levels and found that the network structure informs regulatory function. We show, in 13 tissues, that these eQTL networks are organized into dense, highly mod ...[more]
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