Connectivity in eQTL networks dictates reproducibility and genomic properties.
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ABSTRACT:
SUBMITTER: Gaynor SM
PROVIDER: S-EPMC9142682 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Connectivity in eQTL networks dictates reproducibility and genomic properties.
Gaynor Sheila M SM Fagny Maud M Lin Xihong X Platig John J Quackenbush John J
Cell reports methods 20220523 5
Expression quantitative trait locus (eQTL) analysis associates SNPs with gene expression; these relationships can be represented as a bipartite network with association strength as "edge weights" between SNPs and genes. However, most eQTL networks use binary edge weights based on thresholded FDR estimates: definitions that influence reproducibility and downstream analyses. We constructed twenty-nine tissue-specific eQTL networks using GTEx data and evaluated a comprehensive set of network specif ...[more]
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