Dataset Information

Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.

ABSTRACT: Despite large unmet medical needs in the field for several decades, CNS drug discovery and development has been largely unsuccessful. Biomarkers, particularly those utilizing neuroimaging, have played important roles in aiding CNS drug development, including dosing determination of investigational new drugs (INDs). A recent working group was organized jointly by CINP and Japanese Society of Neuropsychopharmacology (JSNP) to discuss the utility of biomarkers as tools to overcome issues of CNS drug development.The consensus statement from the working group aimed at creating more nuanced criteria for employing biomarkers as tools to overcome issues surrounding CNS drug development. To accomplish this, a reverse engineering approach was adopted, in which criteria for the utilization of biomarkers were created in response to current challenges in the processes of drug discovery and development for CNS disorders. Based on this analysis, we propose a new paradigm containing 5 distinct tiers to further clarify the use of biomarkers and establish new strategies for decision-making in the context of CNS drug development. Specifically, we discuss more rational ways to incorporate biomarker data to determine optimal dosing for INDs with novel mechanisms and targets, and propose additional categorization criteria to further the use of biomarkers in patient stratification and clinical efficacy prediction. Finally, we propose validation and development of new neuroimaging biomarkers through public-private partnerships to further facilitate drug discovery and development for CNS disorders.

SUBMITTER: Suhara T

PROVIDER: S-EPMC5604546 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.

Suhara Tetsuya T Chaki Shigeyuki S Kimura Haruhide H Furusawa Makoto M Matsumoto Mitsuyuki M Ogura Hiroo H Negishi Takaaki T Saijo Takeaki T Higuchi Makoto M Omura Tomohiro T Watanabe Rira R Miyoshi Sosuke S Nakatani Noriaki N Yamamoto Noboru N Liou Shyh-Yuh SY Takado Yuhei Y Maeda Jun J Okamoto Yasumasa Y Okubo Yoshiaki Y Yamada Makiko M Ito Hiroshi H Walton Noah M NM Yamawaki Shigeto S

The international journal of neuropsychopharmacology 20170401 4

Despite large unmet medical needs in the field for several decades, CNS drug discovery and development has been largely unsuccessful. Biomarkers, particularly those utilizing neuroimaging, have played important roles in aiding CNS drug development, including dosing determination of investigational new drugs (INDs). A recent working group was organized jointly by CINP and Japanese Society of Neuropsychopharmacology (JSNP) to discuss the utility of biomarkers as tools to overcome issues of CNS dru ...[more]

PMID: 28031269

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Dataset Information

Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.

Publications

Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.

Similar Datasets

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