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Photocatalytic Aminodecarboxylation of Carboxylic Acids.

ABSTRACT: Aminodecarboxylation of unactivated alkyl carboxylic acids has been accomplished utilizing an organic photocatalyst. This operationally simple reaction utilizes readily available carboxylic acids to chemoselectively generate reactive alkyl intermediates that are not accessible via conventional two-electron pathways. The organic radical intermediates are efficiently trapped with electrophilic diazo compounds to provide aminated alkanes.

SUBMITTER: Lang SB

PROVIDER: S-EPMC5604885 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Photocatalytic Aminodecarboxylation of Carboxylic Acids.

Lang Simon B SB Cartwright Kaitie C KC Welter Richard S RS Locascio Theresa M TM Tunge Jon A JA

European journal of organic chemistry 20160619 20

Aminodecarboxylation of unactivated alkyl carboxylic acids has been accomplished utilizing an organic photocatalyst. This operationally simple reaction utilizes readily available carboxylic acids to chemoselectively generate reactive alkyl intermediates that are not accessible via conventional two-electron pathways. The organic radical intermediates are efficiently trapped with electrophilic diazo compounds to provide aminated alkanes. ...[more]

PMID: 28936118

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