Unknown

Dataset Information

0

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.


ABSTRACT: Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P?

SUBMITTER: Tian C 

PROVIDER: S-EPMC5605711 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.

Tian Chao C   Hromatka Bethann S BS   Kiefer Amy K AK   Eriksson Nicholas N   Noble Suzanne M SM   Tung Joyce Y JY   Hinds David A DA  

Nature communications 20170919 1


Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, ton  ...[more]

Similar Datasets

| S-EPMC7068780 | biostudies-literature
| S-EPMC4795047 | biostudies-literature
| S-EPMC6156406 | biostudies-literature
| S-EPMC4169615 | biostudies-literature
| S-EPMC1196380 | biostudies-literature
| S-EPMC4185120 | biostudies-literature
| PRJNA375837 | ENA
| S-EPMC3266887 | biostudies-literature
| S-EPMC4406292 | biostudies-literature
| S-EPMC3395392 | biostudies-literature