Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
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ABSTRACT:
SUBMITTER: Nicolae D
PROVIDER: S-EPMC1196380 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
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Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Nicolae Dan D Cox Nancy J NJ Lester Lucille A LA Schneider Daniel D Tan Zheng Z Billstrand Christine C Kuldanek Susan S Donfack Joseph J Kogut Paul P Patel Nina M NM Goodenbour Jeffrey J Howard Timothy T Wolf Raoul R Koppelman Gerard H GH White Steven R SR Parry Rodney R Postma Dirkje S DS Meyers Deborah D Bleecker Eugene R ER Hunt Joan S JS Solway Julian J Ober Carole C
American journal of human genetics 20041220 2
Asthma affects nearly 14 million people worldwide and has been steadily increasing in frequency for the past 50 years. Although environmental factors clearly influence the onset, progression, and severity of this disease, family and twin studies indicate that genetic variation also influences susceptibility. Linkage of asthma and related phenotypes to chromosome 6p21 has been reported in seven genome screens, making it the most replicated region of the genome. However, because many genes with in ...[more]
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