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Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds.

ABSTRACT: A series of new coumarin containing compounds were synthesized from 4-bromomethylcoumarin derivatives 2a, b and different heteroaromatic systems 4a-e, 6a-d, 8, 10via methylene thiolinker. Twenty-four compounds were screened biologically against two human tumor cell lines, breast carcinoma MCF-7 and hepatocellular carcinoma HePG-2, at the national cancer institute, Cairo, Egypt using 5-fluorouracil as standard drug. Compounds 5h, 7d, 7h, 9a, 13a and 13d showed strong activity against both MCF-7 and HepG-2 cell lines with being compound 13a is the most active with IC50 values of 5.5 µg/ml and 6.9 µg/ml respectively. Docking was performed with protein 1KE9 to study the binding mode of the designed compounds.

SUBMITTER: Morsy SA

PROVIDER: S-EPMC5605891 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds.

Morsy Shaimaa A SA Farahat Abdelbasset A AA Nasr Magda N A MNA Tantawy Atif S AS

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 20170210 6

A series of new coumarin containing compounds were synthesized from 4-bromomethylcoumarin derivatives 2a, b and different heteroaromatic systems 4a-e, 6a-d, 8, 10via methylene thiolinker. Twenty-four compounds were screened biologically against two human tumor cell lines, breast carcinoma MCF-7 and hepatocellular carcinoma HePG-2, at the national cancer institute, Cairo, Egypt using 5-fluorouracil as standard drug. Compounds 5h, 7d, 7h, 9a, 13a and 13 ...[more]

PMID: 28951673

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Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds.

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Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds.

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