Immunoassay for human serum erythroferrone.
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ABSTRACT:
SUBMITTER: Ganz T
PROVIDER: S-EPMC5606005 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Immunoassay for human serum erythroferrone.
Ganz Tomas T Jung Grace G Naeim Arash A Ginzburg Yelena Y Pakbaz Zahra Z Walter Patrick B PB Kautz Léon L Nemeth Elizabeta E
Blood 20170724 10
Erythroferrone (ERFE) is a glycoprotein hormone secreted by erythroblasts in response to stimulation by erythropoietin (EPO). We previously demonstrated that ERFE messenger RNA expression and serum protein concentration increase in mice subjected to hemorrhage or EPO therapy, that ERFE acts on hepatocytes to suppress hepcidin, and that the resulting decrease in hepcidin augments iron delivery for intensified erythropoiesis. We also showed that ERFE contributes to pathological hepcidin suppressio ...[more]
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