Ontology highlight
ABSTRACT:
SUBMITTER: Moriyama T
PROVIDER: S-EPMC5606007 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Moriyama Takaya T Yang Yung-Li YL Nishii Rina R Ariffin Hany H Liu Chengcheng C Lin Ting-Nien TN Yang Wenjian W Lin Dong-Tsamn DT Yu Chih-Hsiang CH Kham Shirley S Pui Ching-Hon CH Evans William E WE Jeha Sima S Relling Mary V MV Yeoh Allen Eng-Juh AE Yang Jun J JJ
Blood 20170628 10
Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose-limiting hematopoietic toxicities, which is partly explained by inherited genetic polymorphisms in drug metabolizing enzymes (eg, <i>TPMT</i>). Recently, our group and others identified germ line genetic variants in <i>NUDT15</i> as another major cause of thiopurine-related myelosuppression, particularly in Asian and Hispan ...[more]