Ontology highlight
ABSTRACT:
SUBMITTER: Yu CH
PROVIDER: S-EPMC7463237 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Yu Chih-Hsiang CH Chang Ya-Hsuan YH Wang Der-Shiun DS Jou Shiann-Tarng ST Lin Chien-Yu CY Lin Kai-Hsin KH Lu Meng-Yao MY Raghav Lovely L Chang Hsiu-Hao HH Wu Kang-Hsi KH Chou Shu-Wei SW Ni Yu-Ling YL Lin Dong-Tsamn DT Lin Shu-Wha SW Chen Hsuan-Yu HY Yang Yung-Li YL
Scientific reports 20200901 1
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants were identified as a major determinant of mercaptopurine intolerance. Two NUDT15 variants, c.36_37insGGAGTC and c.415C > T, are located on exons 1 and 3, respectively. Patients with heterozygous c.36_37insGGAGTC and c.415C > T can be either compound heterozygous with two variants on different alleles or heterozygous with both variants on the same a ...[more]