Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TQN
PROVIDER: S-EPMC5607247 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Nguyen Thi Quynh Ngoc TQN Lim Kah Wai KW Phan Anh Tuân AT
Scientific reports 20170920 1
Small-molecule ligands targeting nucleic acids have been explored as potential therapeutic agents. Duplex groove-binding ligands have been shown to recognize DNA in a sequence-specific manner. On the other hand, quadruplex-binding ligands exhibit high selectivity between quadruplex and duplex, but show limited discrimination between different quadruplex structures. Here we propose a dual-specific approach through the simultaneous application of duplex- and quadruplex-binders. We demonstrated tha ...[more]