Ontology highlight
ABSTRACT:
SUBMITTER: Balasubramanyam P
PROVIDER: S-EPMC5608098 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Balasubramanyam Penagaluri P Rodríguez Abimael D AD
Tetrahedron 20170114 9
Herein, we report for the first time the design and linear synthesis of a truncated calyculone H (<b>7</b>) that lacks the telltale isopropyl/isopropylene groups, whereas the 12-membered macrocycle remains intact. Key steps for the framework of target molecule include allylic oxidation using SeO<sub>2</sub>, Sharpless asymmetric epoxidation, Barbier zinc allylation, and ring-closing metathesis (RCM) reactions. A second truncated "calyculone-like" analogue, <b>27</b>, with a different oxidation p ...[more]