Ontology highlight
ABSTRACT:
SUBMITTER: Soldevilla MM
PROVIDER: S-EPMC5608357 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Soldevilla Mario Martínez MM Hervas Sandra S Villanueva Helena H Lozano Teresa T Rabal Obdulia O Oyarzabal Julen J Lasarte Juan José JJ Bendandi Maurizio M Inoges Susana S López-Díaz de Cerio Ascensión A Pastor Fernando F
PloS one 20170921 9
LAG3 receptor belongs to a family of immune-checkpoints expressed in T lymphocytes and other cells of the immune system. It plays an important role as a rheostat of the immune response. Focus on this receptor as a potential therapeutic target in cancer immunotherapy has been underscored after the success of other immune-checkpoint blockade strategies in clinical trials. LAG3 showcases the interest in the field of autoimmunity as several studies show that LAG3-targeting antibodies can also be use ...[more]