Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5609535 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wang Chuandong C Yuan Weien W Xiao Fei F Gan Yaokai Y Zhao Xiaotian X Zhai Zhanjing Z Zhao Xiaoying X Zhao Chen C Cui Penglei P Jin Tuo T Chen Xiaodong X Zhang Xiaoling X
Frontiers in pharmacology 20170828
Small-interfering RNA (siRNA) provides a rapid solution for drug design and provides new methods to develop customizable medicines. Polyethyleneimine 25 kDa (PEI25kDa) is an effective transfection agent used in siRNA delivery. However, the lack of degradable linkage causes undesirable toxicity, hindering its clinical application. We designed a low-molecular-weight cross-linked polyethylenimine named PEI-Et (Mn:1220, Mw:2895) by using degradable ethylene biscarbamate linkage with lower cytotoxici ...[more]