Ontology highlight
ABSTRACT:
SUBMITTER: Cromm PM
PROVIDER: S-EPMC5610075 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cromm Philipp M PM Crews Craig M CM
Cell chemical biology 20170622 9
Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and off-target effects can hamper compound efficacy. Nucleic acid-based strategies that control protein function by affecting expression have emerged as an alternative. However, metabolic stability and bro ...[more]