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Chemical inducers of targeted protein degradation.

ABSTRACT: The functions of many cellular proteins have been elucidated by selective gene inactivation and subsequent phenotypic analysis. For example, genetic mutations, gene knock-out generation, and the use of RNA interference to target mRNA for degradation can all result in decreased production of a specific protein, yielding informative cellular phenotypes. However, these techniques each have certain inherent limitations. This minireview focuses on the recent development of new approaches to study protein function at the post-translational level, namely chemical induction of targeted protein degradation.

SUBMITTER: Raina K 

PROVIDER: S-EPMC2856979 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Chemical inducers of targeted protein degradation.

Raina Kanak K   Crews Craig M CM  

The Journal of biological chemistry 20100210 15

The functions of many cellular proteins have been elucidated by selective gene inactivation and subsequent phenotypic analysis. For example, genetic mutations, gene knock-out generation, and the use of RNA interference to target mRNA for degradation can all result in decreased production of a specific protein, yielding informative cellular phenotypes. However, these techniques each have certain inherent limitations. This minireview focuses on the recent development of new approaches to study pro  ...[more]