Ontology highlight
ABSTRACT:
SUBMITTER: Yoon KW
PROVIDER: S-EPMC5610320 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yoon Kyoung Wan KW Yang Hyun-Suk HS Kim Young Mok YM Kim Yeonsil Y Kang Seongman S Sun Woong W Naik Ulhas P UP Parise Leslie V LV Choi Eui-Ju EJ
Scientific reports 20170922 1
Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin α<sub>IIb</sub>. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain remains unclear. Here, we show that CIB1 negatively regulates degeneration of dopaminergic neurons in a mouse model of Parkinson's disease using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Genetic deficiency of the CIB1 gene ...[more]