Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC5610329 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kim Sojin S Kim Ja Eun JE Kim Yong Hwy YH Hwang Taeyoung T Kim Sung Kwon SK Xu Wen Jun WJ Shin Jong-Yeon JY Kim Jong-Il JI Choi Hyoungseon H Kim Hee Chan HC Cho Hye Rim HR Choi Anna A Chowdhury Tamrin T Seo Youngbeom Y Dho Yun-Sik YS Kim Jin Wook JW Kim Dong Gyu DG Park Sung-Hye SH Kim Hyeonjin H Choi Seung Hong SH Park Sunghyouk S Lee Se-Hoon SH Park Chul-Kee CK
Scientific reports 20170922 1
Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment. However, intratumoral heterogeneity of fluorescence intensity may reflect different onco-metabolic programs. Here, we investigated the metabolic mechanism underlying the heterogeneity of 5-ALA fluorescence in GBM. Using an in-house developed fluorescence quantification system for tumor tissues, we collected 3 types of GBM tissues on the basis of their fluorescence inten ...[more]