Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Glioblastoma
SUBMITTER: Saicharan Ghantasala
LAB HEAD: Prof. Sanjeeva Srivastava
PROVIDER: PXD039170 | Pride | 2023-07-20
REPOSITORIES: Pride
Action | DRS | |||
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ALA_Protein_groups.rar | Other | |||
ALA_metadata.xlsx | Xlsx | |||
Human_Proteome_May2022.fasta | Fasta | |||
P10_F_1_1.raw | Raw | |||
P10_F_1_2.raw | Raw |
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Neuro-oncology advances 20230101 1
<h4>Background</h4>Fluorescence-guided surgery (FGS) using 5-aminolevulinic acid (5-ALA) as adjunct for high-grade gliomas (HGGs) has been on the rise in recent years. Despite being largely effective, we observed multiple histologically similar sub-regions of the same tumor from a few individuals with varying protoporphyrin IX (PpIX) levels. The current study aims at understanding the proteomic changes driving differential metabolism of 5-ALA in HGGs.<h4>Methods</h4>Biopsies were histologically ...[more]