Dataset Information

Re-evaluation of soluble APP-? and APP-? in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders.

ABSTRACT:

Background

Because soluble (or secreted) amyloid precursor protein-? (sAPP?) and -? (sAPP?) possibly reflect pathological features of Alzheimer's disease (AD), they are potential biomarker candidates for dementia disorders, including AD and mild cognitive impairment (MCI) due to AD (MCI-AD). However, controversial results have been reported regarding their alterations in the cerebrospinal fluid (CSF) of AD and MCI-AD patients. In this study, we re-assessed the utility of sAPP? and sAPP? in CSF as diagnostic biomarkers of dementia disorders.

Methods

We used a modified and sensitive detection method to analyze sAPPs levels in CSF in four groups of patients: AD (N = 33), MCI-AD (N = 17), non-AD dementia (N = 27), and disease controls (N = 19). Phosphorylated tau (p-tau), total tau, and A?42 were also analyzed using standard methods.

Results

A strong correlation was observed between sAPP? and sAPP?, consistent with previous reports. Both sAPP? and sAPP? were highly correlated with p-tau and total tau, suggesting that sAPPs possibly reflect neuropathological changes in the brain. Levels of sAPP? were significantly higher in MCI-AD cases compared with non-AD and disease control cases, and those of sAPP? were also significantly higher in MCI-AD and AD cases relative to other cases. A logistic regression analysis indicated that sAPP? and sAPP? have good discriminative power for the diagnosis of MCI-AD.

Conclusions

Our findings collectively suggest that both sAPPs are pathologically relevant and potentially useful biomarkers for early and accurate diagnosis of dementia disorders. We also suggest that careful measurement is important in assessing the diagnostic utility of CSF sAPPs.

SUBMITTER: Araki W

PROVIDER: S-EPMC5610422 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders.

Araki Wataru W Hattori Kotaro K Kanemaru Kazutomi K Yokoi Yuma Y Omachi Yoshie Y Takano Harumasa H Sakata Masuhiro M Yoshida Sumiko S Tsukamoto Tadashi T Murata Miho M Saito Yuko Y Kunugi Hiroshi H Goto Yu-Ichi YI Nagaoka Utako U Nagao Masahiro M Komori Takashi T Arima Kunimasa K Ishii Kenji K Murayama Shigeo S Matsuda Hiroshi H Tachimori Hisateru H Araki Yumiko M YM Mizusawa Hidehiro H

Biomarker research 20170922

<h4>Background</h4>Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer's disease (AD), they are potential biomarker candidates for dementia disorders, including AD and mild cognitive impairment (MCI) due to AD (MCI-AD). However, controversial results have been reported regarding their alterations in the cerebrospinal fluid (CSF) of AD and MCI-AD patients. In this study, we re-assessed the utility of sAPPα and sAPPβ ...[more]

PMID: 29018524

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