Ontology highlight
ABSTRACT:
SUBMITTER: Chen YG
PROVIDER: S-EPMC5610545 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Chen Y Grace YG Kim Myoungjoo V MV Chen Xingqi X Batista Pedro J PJ Aoyama Saeko S Wilusz Jeremy E JE Iwasaki Akiko A Chang Howard Y HY
Molecular cell 20170615 2
Circular RNAs (circRNAs) are single-stranded RNAs that are joined head to tail with largely unknown functions. Here we show that transfection of purified in vitro generated circRNA into mammalian cells led to potent induction of innate immunity genes and confers protection against viral infection. The nucleic acid sensor RIG-I is necessary to sense foreign circRNA, and RIG-I and foreign circRNA co-aggregate in cytoplasmic foci. CircRNA activation of innate immunity is independent of a 5' triphos ...[more]