Ontology highlight
ABSTRACT:
SUBMITTER: Katheder NS
PROVIDER: S-EPMC5612666 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Katheder Nadja S NS Khezri Rojyar R O'Farrell Fergal F Schultz Sebastian W SW Jain Ashish A Rahman Mohammed M MM Schink Kay O KO Theodossiou Theodossis A TA Johansen Terje T Juhász Gábor G Bilder David D Brech Andreas A Stenmark Harald H Rusten Tor Erik TE
Nature 20170111 7637
As malignant tumours develop, they interact intimately with their microenvironment and can activate autophagy, a catabolic process which provides nutrients during starvation. How tumours regulate autophagy in vivo and whether autophagy affects tumour growth is controversial. Here we demonstrate, using a well characterized Drosophila melanogaster malignant tumour model, that non-cell-autonomous autophagy is induced both in the tumour microenvironment and systemically in distant tissues. Tumour gr ...[more]