Ontology highlight
ABSTRACT:
SUBMITTER: Doijen J
PROVIDER: S-EPMC5612718 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Doijen Jordi J Van Loy Tom T De Haes Wouter W Landuyt Bart B Luyten Walter W Schoofs Liliane L Schols Dominique D
PloS one 20170925 9
The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors involved in various diseases including human cancer. As such, they have become important targets for therapeutic intervention. Cell-based receptor assays, able to detect agents that modulate receptor activity, are of key importance for drug discovery. We evaluated the potential of cellular electric impedance for this purpose. Dose-dependent and specific stimulation of CXCR4 was detected upon addition of its unique che ...[more]