Ontology highlight
ABSTRACT:
SUBMITTER: Macdonald CB
PROVIDER: S-EPMC5612848 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Macdonald Christian B CB Stockbridge Randy B RB
Current opinion in structural biology 20170514
Dual-topology proteins are likely evolutionary antecedents to a common motif in membrane protein structures, the inverted repeat. A family of fluoride channels, the Flucs, which protect microorganisms, fungi, and plants against cytoplasmic fluoride accumulation, has representatives of all topologies along this evolutionary trajectory, including dual-topology homodimers, antiparallel heterodimers, and, in eukaryotes, fused two-domain proteins with an inverted repeat motif. Recent high-resolution ...[more]