Ontology highlight
ABSTRACT:
SUBMITTER: Peterson JA
PROVIDER: S-EPMC5613515 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Peterson Joshua Allen JA Oblad Richard Vernon RV Mecham Jeffrey Chad JC Kenealey Jason Donald JD
Biochemistry and biophysics reports 20160630
Plasma membrane Ca<sup>2+</sup>-ATPase (PMCA) plays a vital role in maintaining cytosolic calcium concentration ([Ca<sup>2+</sup>] <sub><i>i</i></sub> ). Given that many diseases have modified PMCA expression and activity, PMCA is an important potential target for therapeutic treatment. This study demonstrates that the non-toxic, naturally-occurring polyphenol resveratrol (RES) induces increases in [Ca<sup>2+</sup>] <sub><i>i</i></sub> via PMCA inhibition in primary dermal fibroblasts and MDA-MB ...[more]