Ontology highlight
ABSTRACT:
SUBMITTER: Kishi T
PROVIDER: S-EPMC5613971 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kishi Takayuki T Kawana Hiroki H Sayama Misa M Makide Kumiko K Inoue Asuka A Otani Yuko Y Ohwada Tomohiko T Aoki Junken J
Biochemistry and biophysics reports 20161008
Upon various stimulations, mast cells (MCs) release a wide variety of chemical mediators stored in their cytoplasmic granules, which then initiates subsequent allergic reactions. Lysophosphatidylserine (LysoPS), a kind of lysophospholipid, potentiates the histamine release from MCs triggered by antigen stimulation. We previously showed through structure-activity studies of LysoPS analogs that LysoPS with a methyl group at the carbon of the serine residue, i.e., lysophosphatidylthreonine (LysoPT) ...[more]